I have some Reels that have SESDU3121MXT5G written on the onsemi label,
Im wondering if its the same as the ESDU3121MXT5G which DigiKey has in stock.
The onsemi website lists the S prefix part as custom. See their link
https://www.onsemi.com/search-results#q=SESDU3121MXT5G&sort=relevancy&f:@languagebysource=[English].
I could not tell you what the differences are.