How to connect I2C "hole" to my PC?

Most PC’s do not have any provision for connecting I2C devices because I2C connections are not meant for end users. The exceptions are maker platforms e.g. Raspberry Pi’s.

You will need to get a USB to I2C adapter, here’s a very good one that also works for other popular micro-controller serial busses:
https://www.digikey.com/short/qp4f1hm4

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