Isolation on the digikey 1866-4417-ND

Can the 1866-4417-ND be used on -48 telco batteries to +12v neg ground


Insulation ratings are given on page 1 of the datasheet:

The precise connection you intend is not clear from the description given, but the voltages involved would appear to be well within permissible limits. Note that EMI may also be a factor that should be considered.

I work for a telephone Co. our battery bank runs a positive ground system and I want to run a 12 neg ground radio so the input and output will have to be isolated completely. I can’t tell if that is the case from the literature.
… ART …

Yes, the output of the 1866-4417-ND is (DC) isolated from the input.